Kings of Leon, Little Mix and Stormzy will all perform on 27 and 28 May.
Radio 1 Breakfast Show host Nick Grimshaw announced the news.
"I'm super excited for Big Weekend as it kicks off festival season and always has a mega line-up of the best live music," he said.
"Looking forward to seeing you in Hull for Radio 1's Big Weekend at the end of the May," said Kings of Leon.
"Huge thanks to Radio 1 for leading the charge in helping us get our music to our fans, its going to be a great show, can't wait."